Why is this important?
Although genetic studies have provided important clues to the pathways determining susceptibility and outcome of meningococcal disease, they have mainly been undertaken on relatively small numbers of patients and most have not yet been reproduced in larger studies. There has been increasing awareness that genetic studies should involve larger numbers of patients in order to deliver reliable discoveries.
The recent development of high-throughput methods for whole genome gene scanning, together with computing methods for analyzing and interpreting the information these studies yield, now offer powerful new tools for undertaking such very large genetic studies.
The study will help us to understand the disease in order to develop new therapies and to help identify those who are at risk and those who will develop the most severe disease.
MRF Conference - Nov 2011
Dr Victoria Wright presented some of the results of the work at our international scientific conference
Sept 2010 - Members visit
On 3rd September 2010, a large group of 20 members visited St Mary's Hospital to meet Professor Michael Levin, Dr David Inwald, Dr Nazima Pathan and Dr Simon Nadel.
We heard lots about the work they are doing and about the whole programme of work that MRF has been funding there since the mid 1990's. This included the genetics research but also some of our other funding for a healthcare delivery study.
We also had a tour around the labs from Dr Victoria Wright and saw where the bacteria are worked on and how protected the lab workers have to be.
History of MRF funding
This project is the latest study in a programme of funded work at St Mary's Hospital. Professor Mike Levin received one of our first research grants and has since led several research projects into our genes and how they may influence our susceptibility to meningococcal disease.
See the related projects on the right for Professor Levin's previous work into this important area.
Brian lost his daughter Elizabeth to meningococcal disease