Current research projects

Current Projects

There are currently 20 projects in our active research programme in addition to the MRF Meningococcus Genome Library, an ongoing research resource that was started with MRF funds.

Since the charity was founded in 1989, we have awarded 161 research grants. 

The total value of our investment in vital scientific research is over £19.1 million (€24.5million).

Prevention

Using new genomic techniques to identify the causes of meningitis in UK children.

University of Oxford, UK

Improving detection and treatment.

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Study to evaluate prevention of meningococcal carriage in teenagers (SPIT)

University of Bristol, University of Cambridge UK

Understanding whether the MenB vaccine has an effect on carriage in teenagers

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Could vaccinating teenagers unlock whole population protection against MenB? (SPIT Study lab analysis)

University of Bristol, UK

Does the MenB vaccine affect the carriage of bacteria?

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Are meningococci more abundant in the throats of teenagers with influenza or other common wintertime viruses?

University of Bristol, PHE Bristol, UK, Oxford University

Are people with wintertime viral infections more likely to carry high numbers of meningococcal bacteria and therefore be more infectious?

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Study of the duration of protection after mass vaccination with a new vaccine against epidemic meningitis in the general population of Burkina Faso, a country of the African meningitis belt

Agence de Médecine Préventive, Burkina Faso

Investigating how long protection lasts after vaccination by taking blood samples from children and adults and measuring levels of immunity.

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Investigating transmission of GBS to newborn babies in Malawi

Malawi-Liverpool-Wellcome Trust Programme, Malawi

Using state-of the art genetic fingerprinting techniques to investigate the relationship between GBS bacteria carried by mothers and those causing severe GBS disease in Malawi.

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Assessing the potential benefits of GBS vaccines

University of Cambridge, UK

Evaluating the potential costs and benefits of introducing a GBS (Group B streptococcal) vaccine in the UK. GBS is the leading cause of bacterial meningitis in newborn babies

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Understanding meningococcal disease by simultaneously studying genetic blueprints of patients and the meningococci causing their illness

Public Health England, London, UK; University of Oxford, UK

Linking the MRF Meningococcal Genome Library and the 100k genomes project

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GBS Genome Library

Academic Medical Research Center, Amsterdam, The Netherlands

An online library of the genetic blueprint of Group B streptococcal bacteria

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Vaccinating expectant mothers against MenA

Medical Research Council Unit, The Gambia; Public Health England, Manchester, UK

Protecting newborn infants from meningococcal A infection and meningitis

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Investigating how people value health benefits from childhood vaccination

University of Bristol; University of Cambridge; University of Birmingham

Informing vaccine policy in the future

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Determining whether MenB vaccines can prevent a particular meningococcal strain from causing disease

University of Leicester, UK

Evaluating MenB vaccines

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Investigating the genetic blueprint of meningitis bacteria carried and spread in the African meningitis belt

University of Cambridge, Public Health England, University of Oxford, Wellcome Trust Sanger Institute

Building a comprehensive picture of the genetic differences among bacteria in the African Meningitis Belt.

Investigating the genetic blueprint of disease-causing meningitis bacteria in the African meningitis belt

Norwegian Institute of Public Health, Centres for Disease Control and Prevention (Atlanta), Institute Pasteur (Paris)

Investigating meningitis bacteria that are carried and spread within African communities

Prevention and treatment

Improving understanding of meningococcal disease in Scotland by linking the genetic blueprint of the bug to information about the patient

Health Protection Scotland, Glasgow, UK

Pioneering new MRF-supported genome sequencing research backed by Health Protection Scotland to improve prevention, diagnosis and treatment of meningitis.

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Preventing meningitis in teenagers vaccinated against MenB as babies: is one booster dose enough?

Oxford Vaccine Group, Public Health England, Oxford, UK

Preventing the most common form of bacterial meningitis in the UK

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Detection

MRF funds pioneering new research that could eventually help stop loss of limbs from meningitis

Instituit Necker, Paris, France

Understanding meningococcus-induced blood clotting - Working towards new therapeutics for purpura fulminans

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Treatment

Defining meningitis in UK children in the conjugate vaccine era

University of Oxford, UK

Describing the symptoms, clinical signs and laboratory results of all children with meningitis. Investigating differences between children with bacterial and viral meningitis to determine how to differentiate these two groups.

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MRF funds pioneering new research that could eventually help stop loss of limbs from meningitis

Instituit Necker, Paris, France

Understanding meningococcus-induced blood clotting - Working towards new therapeutics for purpura fulminans

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Improving Survival in HIV-infected Adults at Risk of Cryptococcal Meningitis

St George's University of London, London, UK, National Institution for Communicable Diseases, Johannesburg, South Africa

Investigating the causes of severe illness and death in HIV-infected cryptococcal positive patients.

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Page last updated 17.07.17