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meningitis & septicaemia can kill in hours!

People who are faced with meningitis and septicaemia have to act fast to help save a life.

Scientific Version


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Minor pilins as novel vaccine candidates against Neisseria meningitidis

Imperial College, London, UK

Besides the polysaccharide capsule, on which all the currently available vaccines are based, type IV pili (Tfp) are the only known surface-exposed structures present on all virulent meningococcal...


Transcriptional signatures for diagnosis and assessing disease severity in bacterial meningitis.

Baylor Institute for Immunology Research, Dallas, USA, University of Texas Southwestern Medical Centre, Dallas, USA

The purpose of this study is to take advantage of innovative transcriptional genomic approaches that we recently developed to identify blood biomarkers for diagnosis and prognosis of patients with...


Evaluation of corticosteroid therapy in childhood severe sepsis - a randomised pilot study.

University of Southampton, Southampton, UK, Bristol University, Bristol, UK, St Mary’s Hospital, London, UK

This project is an open randomised prospective pilot exploratory clinical trial of corticosteroid replacement therapy in paediatric sepsis (including meningococcal sepsis) to be carried out in three...


Neuro-cognitive function in children following hospital admission with septic illness and meningo-encephalitis.

Imperial College, London, UK

Little is known about cognitive function following acute severe paediatric illness in school children and adolescents. A pilot study by the applicants has documented visual and verbal memory and...


Biological stress markers and neuro-cognitive/psychiatric sequelae in critically ill children

Imperial College School of Medicine at St Mary's Hospital, London, UK

Improvements in medical care have reduced mortality from critical illness in childhood. Nevertheless, research by our group has identified high rates of subsequent psychiatric disorders and...


Development and clinical validation of a rapid qualitative near-patient molecular test to detect Neisseria meningitidis.

Queen's University, Belfast, UK

We propose the development and clinical validation of a rapid qualitative molecular test to detect Neisseria meningitidis DNA in patient specimens, allowing rapid (


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