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meningitis & septicaemia can kill in hours!

People who are faced with meningitis and septicaemia have to act fast to help save a life.

Scientific Version


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Natural immunity against serogroup X Neisseria meningitidis

Oxford University, Oxford, UK

Previously an infrequent cause of meningococcal disease, serogroup X N. meningitidis has recently emerged as a cause of increased incidence or large outbreaks of disease, particularly in Niger, Togo...


Role of S-nitrosothiol depletion in meningococcal sepsis and potential for novel therapy

University of Sheffield, Sheffield, UK

Meningococcal sepsis is associated with severe and rapid physiological disruption and microcirculatory failure that is often non-refractory despite intensive resuscitation.  Nitric oxide (NO) is...


Using lipo-oligosaccharide modification to generate a novel vaccine to protect against serogroup B meningococcal disease

Institute of Child Health, London, UK

Neisseria meningitidis remains a common cause of bacterial meningitis and septicaemia in children. Although conjugate capsular vaccines for serogroups A and C have been successfully developed, a safe...


Prevalence and prognostic significance of viral co-infection of the brain in HIV-infected adults with bacterial meningitis in Malawi

Liverpool School of Tropical Medicine, Liverpool, UK, Queen Elizabeth Central Hospital, Malawi-Liverpool-Wellcome Research Laboratories, College of Medicine, Blantyre, Malawi

Bacterial meningitis is associated with an unacceptably high rate of death and disability in sub-Saharan Africa. Previous MRF-funded studies have found no benefit from either adjunctive...


Characterisation and vaccine potential of pneumococcal virulence factors expressed during meningitis

Adelaide University, Adelaide, Australia

Streptococcus pneumoniae is now the commonest cause of meningitis in children and older adults. The prevalence of antibiotic-resistant pneumococci is increasing rapidly, and available vaccines have...


Group B Streptococcal carriage and HIV-infection in pregnant women in Malawian women

London School of Hygiene & Tropical Medicine, London, UK, Queen Elizabeth Central Hospital, Malawi-Liverpool-Wellcome Research Laboratories, College of Medicine, Blantyre, Malawi

Group B Streptococci (GBS) are the most important identified infectious cause of neonatal death in Blantyre, Malawi. The incidence of meningitis and septicaemia (1.8/1000 live births) is similar to...


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