HELP DEFEAT MENINGITIS
UK 080 8800 3344ROI 1800 41 33 44
People who are faced with meningitis and septicaemia have
to act fast to help save a life.
Know the symptoms
Home Research Scientific Version Understanding cross-protective natural immunity conferred by Neisseria lactamica to develop meningococcal vaccines.
The purpose of this project is to understand the basis of natural anti-meningococcal immunity that is conferred by infection with N. lactamica. The project takes advantage of i) our recent findings that certain, but not all, strains of this commensal can elicit serum bactericidal activity (SBA) in immunised animals, and ii) samples from ongoing clinical studies (a Phase 1 trial of N. lactamica OMVs and a study on colonisation of human volunteers with N. lactamica) that will provide important information on human responses to N. lactamica. We will characterise the specific immune responses against this commensal that also recognise N. meningitidis antigens by immunoproteome analysis, and will compare the genetic composition of N. lactamica strains that do or do not confer SBA. Identification of antigens that confer cross-protective should contribute to the development of meningococcal vaccines.
My brave little girl has never stopped smiling
News and information directly to your inbox:
Sign up for updates
The Sience of Saving Lives
©2014 Meningitis Research Foundation
Offices: Belfast, Bristol, Dublin, Edinburgh.
A charity registered in England and Wales no 1091105, in Scotland no SC037586, & in Ireland CHY 12030
A company limited by guarantee, registered in England no 4367866
Registered Office: Midland Way, Thornbury, Bristol, BS35 2BS