Donate online today. €150 buys 20 packs for GP surgeries

meningitis & septicaemia can kill in hours!

People who are faced with meningitis and septicaemia have to act fast to help save a life.

Understanding cross-protective natural immunity conferred by Neisseria lactamica to develop meningococcal vaccines.

  • Researchers:
    Dr Andy Gorringe, Dr Yanwen Li, Prof Chris Tang, Prof Ian Feavers
  • Start Date:
    01 January 2006
  • Category:
    Prevention
  • Location:
    National Institute for Biological Standards and Control, Hertfordshire, UK, Health Protection Agency, Salisbury, UK, Imperial College, London, UK
Understanding cross-protective natural immunity conferred by Neisseria lactamica to develop meningococcal vaccines.

The purpose of this project is to understand the basis of natural anti-meningococcal immunity that is conferred by infection with N. lactamica. The project takes advantage of i) our recent findings that certain, but not all, strains of this commensal can elicit serum bactericidal activity (SBA) in immunised animals, and ii) samples from ongoing clinical studies (a Phase 1 trial of N. lactamica OMVs and a study on colonisation of human volunteers with N. lactamica) that will provide important information on human responses to N. lactamica. We will characterise the specific immune responses against this commensal that also recognise N. meningitidis antigens by immunoproteome analysis, and will compare the genetic composition of N. lactamica strains that do or do not confer SBA. Identification of antigens that confer cross-protective should contribute to the development of meningococcal vaccines.

Jaxon Roy Kelly
Meningococcal disease
Meningococcal disease at 2yrs and 4m

The Remembrance Fund for Jaxon Roy Kelly

More stories
Search research projects
Meet us on Facebook