Social, psychological and functional outcomes after meningococcal disease in adolescents: a longitudinal case-control study
Dr Deborah Christie, Dr Russell Viner, Professor Robert Booy
- Start Date:
01 January 2000
University College, London, UK
Background: Little is known about the long-term consequences of MD, particularly in adolescence. Subtle neuropsychological sequelae may have a significant impact on later social, educational and employment functioning, but have been little studied. Our current Adolescent MD Risk-factor study provides an excellent opportunity to study these outcomes.
Objectives: (1) To explore medium term (12-18 months) prevalence of educational and employment disadvantage, social isolation, stress and depression, and reduced quality of life after MD. (2) To investigate the prevalence of neurological and neuropsychological deficits in IQ, multiple aspects of memory, attention, verbal and visual recognition ability and executive function after MD in late adolescence and their association with social and psychological outcomes.
Methodology: Longitudinal case-control study. 160 cases & 160 controls will be drawn from the existing risk-factor study (95% have given provision assent). Outcomes will be measured through a supervised questionnaire and a battery of neuropsychological tests (time 2). Premorbid (time 1) data will be drawn from the Risk-factor study. Outcomes will include social, educational and employment functional status, tobacco, drug & alcohol use, psychological variables (quality of life, social support, self-efficacy, functional disability, depression, psychopathology) and neuropsychological variables (multiple aspects of memory, attention, verbal and visual recognition ability and executive function). This sample is sufficient to provide 95% significance at 80% power. Analysis will be undertaken through comparison of group means between cases and controls and between time 1 and time 2.