Identification of the genes controlling meningococcal disease susceptibility and severity.
Dr Simon Nadel, Professor Michael Levin, Professor Simon Kroll
- Start Date:
01 January 2004
Imperial College, London, UK
There is now clear evidence that genetic factors play an important role in determining susceptibility, clinical course and outcome of infectious diseases including meningococcal sepsis. Identification of the genes responsible may provide important clues to the immunopathophysiological mechanisms involved, help to identify those as susceptible, and enable new therapeutic targets to interrupt disordered physiology to be identified. The proposed programme of work will utilise two large cohorts of highly characterised patients with meningococcal disease and their families, that have been established over the past decade, to identify genes controlling susceptibility and outcome of meningococcal disease. In collaboration with a number of international research groups, we will utilise a range of High throuput genotyping methods to study the role of candidate genes controlling the inflammatory and coagulation response, underlying susceptibility and severity of meningococcal disease.