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Does B and T cell function of adults predict a poor response to the C conjugate meningococcal vaccine?

  • Researchers:
    Dr Andrew Heath, Dr James Wing, Dr Ray Borrow, Lynne Smart, Prof Rob Read
  • Start Date:
    01 January 2006
  • Category:
  • Location:
    University of Sheffield, Sheffield, UK, HPA Vaccine Evaluation Department, London, UK
Does B and T cell function of adults predict a poor response to the C conjugate meningococcal vaccine?

From UK efficacy data, and from our own work in which we have measured  responses to C polysaccharide challenge amongst recipients of the meningococcal C conjugate vaccine (MCC),  it is concluded that some adult recipients, one year after vaccination, have non-protective SBA titres and/or no memory response. To improve our understanding of the host determinants of successful response to conjugate meningococcal vaccines, we seek to determine in a prospective sample of 100 university students undergoing MCC vaccination, whether SBA titres and memory responses one year after vaccination with MCC correlate with one or more of (i)  innate host B cell activation and proliferation in response to  T independent antigens, and/or (ii) potency of  co-stimulation of  T cells by activated B cells, and/or (iii) quality of  T cell help to B cells.  Furthermore we will compare the kinetics of systemic and mucosal antibody responses during re-challenge one year after MCC, and if a pattern of poor mucosal response emerges, we will likewise correlate with B/T cell co-stimulatory function.  This work will investigate cellular correlates of responses to conjugate vaccines and suggest future strategies for the development of improved vaccines.

Lauren Maltby
Bacterial Meningitis
Bacterial Meningitis at 28

To this day there are no words I can use to describe the persistent and excruciating pain...

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