HELP DEFEAT MENINGITIS
UK 080 8800 3344ROI 1800 41 33 44
People who are faced with meningitis and septicaemia have
to act fast to help save a life.
Know the symptoms
Home Research Scientific Version Detection of meningococcal serogroups A, Y, W135 and pneumococcal bacteria by ultrasound latex agglutination; Comparison with PCR
The serogrouping of meningococcal groups A, Y and W135 in clinical blood samples will be investigated by ultrasonic standing wave agglutination of commercially available and in-house prepared individual antibody-coated latex bead suspensions. Conditions for detection of pneumococci, and Strep agalactiae (Lancefield group B) by ultrasonic agglutination of commercially available latex kits kits will be optimised. In further experiments, latex particles will be coated by monocional antibody to the pneumococcal toxin, pneumolysin. The lower limits of pneumococcal bacteria detectable by ultrasonic agglutination of these particles will be established and compared with detection of currently available beads which are coated with polyclonal antibody to capsular polysaccharides. The sensitivity and specificity of the ultrasonic technique in clinical samples containing the above antigens will be compared with PCR detection of bacterial DNA in samples obtained by Manchester PHLS Meningococcal Reference Unit (MRU).
Never did we think our precious son would not hear our voices again
News and information directly to your inbox:
Sign up for updates
The Sience of Saving Lives
©2014 Meningitis Research Foundation
Offices: Belfast, Bristol, Dublin, Edinburgh.
A charity registered in England and Wales no 1091105, in Scotland no SC037586, & in Ireland CHY 12030
A company limited by guarantee, registered in England no 4367866
Registered Office: Midland Way, Thornbury, Bristol, BS35 2BS